Molecular Formula | C19H26N2O4S |
Molar Mass | 378.49 |
Storage Condition | Store at +4°C |
biological activity | Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol enhanced ICa with an EC50 of 2.2 nM. |
Target | β2-adrenoceptor |
Animal Model: | In New Zealand White HF rabbits of either sex |
Dosage: | 1.0 or 2.5 μg/kg |
Administration: | Intravenous bolus administration; over 5 seconds |
Result: | 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits. 2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |